In particular, she examines the class privilege that attends both queer theory’s and university’s deployment of travel metaphors. In both cases, the language of travel is the potentially empowering language of intellectual agility and social mobility.
Importantly, though, both queer theorists’ and university administrators’ employment of travel metaphors often serves to reaffirm cultural hegemony, specifically to sustain rather than to examine and combat social oppression.
This sad irony is particularly apparent when one compares university representations of commuter and residential students. Thus, the… question that faces universities is how to keep queer studies critically queer so that universities can recognize and address the various forms or models of social mobility that are present on their campuses, commuter as well as residential.
It has been suggested by studies in animals and humans that substance P (SP) and its receptor neurokinin 1 (NK1R) play an important role in the pathology of depression. The pharmacological blockade or genetic deletion of the NK1 receptor, or the substance P coding gene tac1 led to a decreased emotionality and a reduction of depression-related behaviours in different animal models.
In order to characterize molecular changes associated with reduced SP-NK1 signalling in animal models of depression, we assessed the regulation of the CRH system. First, tac1(-/-) animals and tac1(+/+) controls were subjected to bulbectomy, which induces physiological and behavioural changes that are relevant to depression. We demonstrate that tac1(-/-) animals, in contrast to tac1(+/+) controls, do not show… anhedonia in the saccharine preference test after bulbectomy. Next, we studied expression levels of CRH, the receptors CRHR1 and CRHR2, and the binding protein CRHBP in the cortex and paraventricular nucleus using real-time RT-PCR.
Our results show a strong induction of CRH, CRHBP and CRHR1 expression in the cortex of tac1(-/-), but not in tac1(+/+) animals. In the PVN, bulbectomized tac1(-/-) mice showed an elevated expression of CRHR1 and CRHR2. These results show that substance P/NKA is involved in modulating CRH signalling in an animal model of depression.
This paper gives a survey of the Mars Express orbit design, as it evolved from before launch to arrival at Mars. The orbit selection for Mars Express has major scientific impacts, as the orbit is elliptical, with continuous changes of the latitude and local hour of the pericentre. A first target orbit was defined in 1999 by combining scientific and engineering constraints.
As a very favourable launch date was achieved and the launcher injection error was ‘better than nominal’ (the error removed part of the planned re-targeting), propellant reserves turned out to be available after launch. Part of this was used to improve the target orbit. The plane turn manoeuvre was increased to start with the pericentre near the equator rather… than at 20°S latitude, with the objective of increasing the early observation phase with good day-side viewing conditions.
A few weeks after launch, an anomaly in the spacecraft power system was detected, with a loss of up to 40% in terms of available power. This led to a series of studies on back-up orbits, to the extreme of Sun-synchronous eclipse free orbits. Luckily the problem could be solved at the spacecraft engineering level and the orbit with the best science return could be reached in early February 2004.
Previous studies suggest that membrane lipids may regulate proteolytic processing of the amyloid precursor protein (APP) to generate amyloid-beta peptide (Abeta). In the present study, we have assessed the capacity for a series of structurally related synthetic ceramide analogues to modulate APP processing in vitro.
The compounds tested are established glucosylceramide synthase (GS) inhibitors based on the d -1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) structure. PDMP and related compounds PPMP and EtDO-P4 inhibited Abeta secretion from Chinese hamster ovary cells expressing human APP (CHO-APP) with approximate IC 50 values of 15, 5, and 1μM, respectively. A trend for reduced secretion of the APP alpha-secretase product, sAPPalpha, was also observed in… PDMP-treated cells but not in PPMP- or ETDO-P4-treated cells, whereas levels of the cellular beta-secretase product APP C-terminal fragment, CTFbeta, were increased by both PDMP and PPMP but unaltered with EtDO-P4 treatment.
Our data also revealed that EtDO-P4 inhibits endogenous Abeta production by human neurons. In conclusion, this study provides novel information regarding the regulation of APP processing by synthetic ceramide analogues and reveals that the most potent of these compounds is EtDO-P4.
A map that shows the necessary condition for avoiding the generation of low-frequency stick-slip of a creep groan is introduced. The map is obtained as a result of comprehensive investigation employing a novel caliper-slider experimental model.
According to the map, creep groan generation is controlled by two dimensionless parameters, designated as stiffness ratio, Sr, and low-frequency stick-slip index, Ls. Stiffness ratio, Sr, is the ratio of structure stiffness to the stiffness at contact interface and Ls is an index formed by various parameters such as normal force, sliding velocity, and difference between static and kinetic coefficients of friction.
On the experimental model, creep groan generation can be avoided if one or both of the following conditions is fulfilled: (a) stiffness… 400). It is expected that the map can be used as a useful guideline for avoiding the generation of similar phenomenon on a real brake system. [PUBLICATION ABSTRACT]